Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.57 |
| ▸ | TUBB | P07437 | 1/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619090 | 0.90 | KDR (0.60) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL484701 | 0.82 | MAP3K11 (0.55) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL3427648 | 0.78 | TUBB4A (0.68) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL797894 | 0.78 | KDR (0.54) | KDM4EHTTKDRHTR2AHTR2C | |
| SCHEMBL7292576 | 0.78 | PARP1 (0.46) | KDM4EHPGDMEN1KMT2AKDR | |
| SCHEMBL30451928 | 0.77 | KDM4E (0.50) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL4287798 | 0.77 | KDM4E (0.50) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL7294516 | 0.74 | CDC7 (0.52) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL7286094 | 0.74 | CDC7 (0.52) | KDM4EHPGDHTTMEN1CYP1A2 | |
| SCHEMBL7283436 | 0.74 | CDC7 (0.52) | KDM4EHPGDHTTMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148543-B1 | SMALL MOLECULE TRANSCRIPTION MODULATORS OF BROMODOMAINS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-04-08 | — | — | EP | disclosed |
| US-10065951-B2 | Small molecule transcription modulators of bromodomains | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-09-04 | — | — | US | disclosed |
| US-20170107218-A1 | Small Molecule Transcription Modulators of Bromodomains | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-20 | — | — | US | disclosed |
| US-20170107218-A1 | Small Molecule Transcription Modulators of Bromodomains | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-20 | — | — | US | disclosed |
| US-20170107218-A1 | Small Molecule Transcription Modulators of Bromodomains | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-20 | — | — | US | disclosed |
| EP-3148543-A2 | SMALL MOLECULE TRANSCRIPTION MODULATORS OF BROMODOMAINS | Icahn School of Medicine at Mount Sinai (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015184257-A2 | SMALL MOLECULE TRANSCRIPTION MODULATORS OF BROMODOMAINS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015184257-A2 | SMALL MOLECULE TRANSCRIPTION MODULATORS OF BROMODOMAINS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2015-12-03 | — | — | WO | disclosed |
| US-8946260-B2 | 17α-hydroxylase/C17,20-lyase inhibitors | NOVARTIS AG (CH) | 2015-02-03 | — | — | US | disclosed |
| US-20140315889-A1 | HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2014-10-23 | — | — | US | disclosed |
| US-20100113478-A1 | INDOLONE MODULATORS OF 5-HT3 RECEPTOR | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| EP-0458624-B1 | Process for the preparation of lactam derivatives | GLAXO GROUP LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| EP-0306323-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1994-09-21 | — | — | EP | disclosed |
| US-5196534-A | PROCESS FOR THE PREPARATION OF LACTAM DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-03-23 | — | — | US | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0458624-A1 | Process for the preparation of lactam derivatives | GLAXO GROUP LIMITED (GB) | 1991-11-27 | — | — | EP | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |
| EP-0306323-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315889-A1 | HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | HDAC1, HDAC5, HDAC3 | KDM4E 229/4885HPGD 191/4885HTT 50/4885 |
| US-20170107218-A1 | Small Molecule Transcription Modulators of Bromodomains | NFRKB, NFKBIA, RELA | KDM4E 1539/4885HPGD 1327/4885HTT 1041/4885 |
| US-20100113478-A1 | INDOLONE MODULATORS OF 5-HT3 RECEPTOR | HTR3A, HTR3B, HTR3E | KDM4E 2349/4885HPGD 911/4885HTT 779/4885 |
| US-10065951-B2 | Small molecule transcription modulators of bromodomains | NFRKB, NFKBIA, RELA | KDM4E 1539/4885HPGD 1327/4885HTT 1041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.