Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849953 | 1.00 | BCHE (0.46) | BCHEACHEMAPTPDE4APDE4B | |
| SCHEMBL4847107 | 0.93 | SYK (0.41) | BCHEACHESYK | |
| SCHEMBL4849440 | 0.93 | SYK (0.41) | BCHEACHESYK | |
| SCHEMBL4847751 | 0.89 | TUBB1 (0.51) | BCHEACHEMAPTPDE4APDE4B | |
| SCHEMBL4847787 | 0.89 | TUBB1 (0.51) | BCHEACHEMAPTPDE4APDE4B | |
| SCHEMBL4854085 | 0.88 | ABCG2 (0.51) | BCHEACHEMAPTPDE4APDE4B | |
| SCHEMBL4853352 | 0.88 | ABCG2 (0.51) | BCHEACHEMAPTPDE4APDE4B | |
| SCHEMBL4857422 | 0.86 | BCHE (0.49) | BCHEACHEMEN1LMNAKMT2A | |
| SCHEMBL4852790 | 0.86 | BCHE (0.49) | BCHEACHEMEN1LMNAKMT2A | |
| SCHEMBL4849963 | 0.85 | SYK (0.44) | BCHEACHESYKABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |