Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 8/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846870 | 1.00 | CHRNA7 (0.43) | CHRNA7SYKBCHEGUSBAR | |
| SCHEMBL4852245 | 0.93 | SYK (0.45) | SYKBCHEARSLC6A9MAOB | |
| SCHEMBL4849808 | 0.93 | SYK (0.45) | SYKBCHEARSLC6A9MAOB | |
| SCHEMBL4849704 | 0.90 | KDM4E (0.47) | SYKBCHEARSLC6A9ACHE | |
| SCHEMBL4853093 | 0.90 | KDM4E (0.47) | SYKBCHEARSLC6A9ACHE | |
| SCHEMBL4852546 | 0.89 | SYK (0.44) | SYKBCHEARSLC6A9ACHE | |
| SCHEMBL4852420 | 0.89 | SYK (0.42) | SYKBCHEARSLC6A9ACHE | |
| SCHEMBL4847247 | 0.89 | SYK (0.44) | SYKBCHEARSLC6A9ACHE | |
| SCHEMBL4849970 | 0.89 | SYK (0.44) | SYKBCHESLC6A9MAOBACHE | |
| SCHEMBL4852900 | 0.89 | SYK (0.44) | SYKBCHESLC6A9MAOBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |