Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852546 | 1.00 | SYK (0.44) | SYKARHTR7SLC6A9BCHE | |
| SCHEMBL4852245 | 0.92 | SYK (0.45) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4849808 | 0.92 | SYK (0.45) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4847248 | 0.89 | HTR7 (0.43) | SYKARHTR7SLC6A9BCHE | |
| SCHEMBL4853093 | 0.89 | KDM4E (0.47) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4849704 | 0.89 | KDM4E (0.47) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4846870 | 0.89 | CHRNA7 (0.43) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4847743 | 0.89 | CHRNA7 (0.43) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4852420 | 0.89 | SYK (0.42) | SYKARSLC6A9BCHEACHE | |
| SCHEMBL4852900 | 0.89 | SYK (0.44) | SYKSLC6A9BCHEACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |