Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 12/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 11/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783698 | 0.89 | PLK1 (0.56) | PLK1PLK3PLK2BRD4ALK | |
| SCHEMBL3547205 | 0.86 | RAD52 (0.51) | PLK1PLK3PLK2BRD4ALK | |
| SCHEMBL4794798 | 0.83 | PLK1 (0.64) | PLK1PLK3PLK2BRD4ALK | |
| SCHEMBL4783441 | 0.82 | PLK1 (0.62) | PLK1PLK3PLK2BRD4 | |
| SCHEMBL4783982 | 0.81 | PLK1 (0.65) | PLK1PLK3PLK2BRD4ALK | |
| SCHEMBL4782269 | 0.81 | PLK1 (0.58) | PLK1PLK3PLK2BRD4 | |
| SCHEMBL3546254 | 0.80 | RAD52 (0.57) | PLK1PLK3PLK2BRD4 | |
| SCHEMBL3543550 | 0.79 | PLK1 (0.62) | PLK1PLK3PLK2BRD4 | |
| SCHEMBL3542917 | 0.79 | PLK1 (0.62) | PLK1PLK3PLK2BRD4 | |
| SCHEMBL4784171 | 0.78 | PLK1 (0.61) | PLK1PLK3PLK2BRD4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |