Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849713 | 0.86 | KCNH2 (0.43) | KCNH2ALDH1A1HTR1AADRA1DADRA1A | |
| SCHEMBL5813519 | 0.85 | KCNH2 (0.43) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4854654 | 0.84 | SRC (0.41) | ALDH1A1TP53CYP3A4ALOX15TSHR | |
| SCHEMBL27579215 | 0.82 | KCNH2 (0.46) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL2535928 | 0.82 | KCNH2 (0.43) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL2533923 | 0.82 | KCNH2 (0.46) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6267955 | 0.80 | KCNH2 (0.48) | KCNH2LMNA | |
| SCHEMBL2954867 | 0.79 | KDM4E (0.42) | ALDH1A1TP53HTR1AADRA1DADRA1A | |
| SCHEMBL14249652 | 0.76 | KDM4E (0.42) | ALDH1A1TP53CYP3A4ALOX15TSHR | |
| SCHEMBL4851061 | 0.75 | ROCK2 (0.44) | KCNH2TSHRMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348434-B2 | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them | BIGOT ANTONY | 2008-03-25 | — | — | US | disclosed |
| EP-1654252-A2 | SUBSTITUTED QUINOLINES SERVING AS ANTIMICROBIAL AGENTS | NOVEXEL (FR) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016916-A2 | SUBSTITUTED QUINOLINES SERVING AS ANTIMICROBIAL AGENTS | NOVEXEL (FR) | 2005-02-24 | — | — | WO | disclosed |
| US-20050032800-A1 | 4-Substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them | AVENTIS PHARMA S. A. (FR) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032800-A1 | 4-Substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them | CBR3, HRH2, HRH4 | KCNH2 272/4885ALDH1A1 2345/4885TP53 4162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.