Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | USP14 | P54578 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15374360 | 0.92 | CYP19A1 (0.49) | CYP19A1DYRK1AUSP14SCN9AKDM1A | |
| SCHEMBL4856398 | 0.77 | CYP11B1 (0.53) | CYP19A1DYRK1ACYP11B2GSK3BKCNH2 | |
| SCHEMBL4855278 | 0.75 | CYP11B1 (0.42) | CYP19A1DYRK1ACHUKCYP11B2GSK3B | |
| SCHEMBL4856202 | 0.73 | TBXAS1 (0.50) | CYP19A1DYRK1AGSK3B | |
| SCHEMBL12069244 | 0.71 | SCN9A (0.53) | CYP19A1DYRK1AUSP14SCN9AKDM1A | |
| SCHEMBL15977199 | 0.70 | CYP19A1 (0.50) | CYP19A1USP14CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL4849426 | 0.69 | CYP17A1 (0.38) | DYRK1AGSK3BKCNH2ELANE | |
| SCHEMBL4857588 | 0.68 | CYP19A1 (0.50) | CYP19A1DYRK1ACYP11B2GSK3BKCNH2 | |
| SCHEMBL4854778 | 0.68 | DYRK1A (0.41) | DYRK1AGSK3BKCNH2KDM4EALDH1A1 | |
| SCHEMBL2877666 | 0.66 | DYRK1A (0.59) | DYRK1AGSK3BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CYP19A1 1766/4885DYRK1A 1117/4885USP14 2184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.