Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP4 | P49662 | 1/20 | 0.31 |
| ▸ | CASP5 | P51878 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852535 | 1.00 | IDH1 (0.34) | IDH1NR1H2NR1H3OPRD1NTSR1 | |
| Hydrochloric Acid SCHEMBL4857620 | 0.99 | IDH1 (0.34) | IDH1NR1H2NR1H3OPRD1NTSR1 | |
| Hydrochloric Acid SCHEMBL4851035 | 0.99 | IDH1 (0.34) | IDH1NR1H2NR1H3OPRD1NTSR1 | |
| Hydrochloric Acid SCHEMBL4851030 | 0.99 | IDH1 (0.34) | IDH1NR1H2NR1H3OPRD1NTSR1 | |
| SCHEMBL5016672 | 0.91 | IDH1 (0.35) | IDH1NR1H2NR1H3OPRD1OPRK1 | |
| SCHEMBL5016670 | 0.91 | IDH1 (0.35) | IDH1NR1H2NR1H3OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5024778 | 0.90 | IDH1 (0.35) | IDH1NR1H2NR1H3OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5014904 | 0.90 | IDH1 (0.35) | IDH1NR1H2NR1H3OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5014905 | 0.90 | IDH1 (0.35) | IDH1NR1H2NR1H3OPRD1OPRK1 | |
| SCHEMBL4260642 | 0.89 | OPRD1 (0.33) | NR1H2NR1H3OPRD1NTSR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1698620-B1 | BENZENE COMPOUNDS DISUBSTITUTED WITH CYCLIC GROUPS AT THE 1- AND 2-POSITIONS | EISAI R&D MAN CO LTD (JP) | 2016-09-28 | — | — | EP | disclosed |
| US-7425554-B2 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-09-16 | — | — | US | disclosed |
| US-20060276465-A1 | 1,2-di(cyclic) substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-12-07 | — | — | US | disclosed |
| EP-1698620-A1 | BENZENE COMPOUNDS DISUBSTITUTED WITH CYCLIC GROUPS AT THE 1- AND 2-POSITIONS | Eisai Co., Ltd. (JP) | 2006-09-06 | — | — | EP | disclosed |
| US-20050261291-A1 | 1,2-Di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261291-A1 | 1,2-Di(cyclic)substituted benzene compounds | CCR10, HRH3, HRH2 | IDH1 3104/4885NR1H2 96/4885NR1H3 104/4885 |
| US-20060276465-A1 | 1,2-di(cyclic) substituted benzene compounds | HRH3, CCR10, HRH1 | IDH1 2256/4885NR1H2 102/4885NR1H3 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.