Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 14/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332380 | 0.82 | MAPT (0.62) | ERN1MAPTSMN1; SMN2CDK1TRIM24 | |
| SCHEMBL209836 | 0.82 | ESR1 (0.55) | ERN1MAPTSMN1; SMN2CDK1ESR2 | |
| SCHEMBL11417093 | 0.80 | MAPT (0.61) | ERN1MAPTSMN1; SMN2CDK1 | |
| SCHEMBL16130218 | 0.80 | ERN1 (0.50) | ERN1MAPTSMN1; SMN2CDK1TRIM24 | |
| SCHEMBL8331029 | 0.79 | ERN1 (0.41) | ERN1 | |
| SCHEMBL14849044 | 0.79 | ERN1 (0.49) | ERN1MAPTSMN1; SMN2CDK1TRIM24 | |
| SCHEMBL13257343 | 0.77 | ERN1 (0.55) | ERN1MAPTSMN1; SMN2CDK1TRIM24 | |
| SCHEMBL3696806 | 0.77 | ALDH1A1 (0.46) | ERN1 | |
| SCHEMBL3648582 | 0.76 | ERN1 (0.46) | ERN1MAPTSMN1; SMN2CDK1TRIM24 | |
| SCHEMBL9374541 | 0.76 | ERN1 (0.50) | ERN1MAPTSMN1; SMN2CDK1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |