Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853051 | 0.90 | MEN1 (0.44) | PTPN1MEN1KMT2ALMNAHPGD | |
| SCHEMBL4852755 | 0.90 | MEN1 (0.44) | PTPN1MEN1KMT2ALMNAHPGD | |
| SCHEMBL4855883 | 0.83 | HPGD (0.52) | PTPN1MEN1KMT2ALMNAHPGD | |
| SCHEMBL4849956 | 0.83 | LMNA (0.53) | MEN1KMT2ALMNAHPGDALDH1A1 | |
| SCHEMBL4847397 | 0.81 | LMNA (0.49) | PTPN1MEN1KMT2ALMNAHPGD | |
| SCHEMBL4854497 | 0.80 | MEN1 (0.48) | MEN1KMT2ALMNAHPGDALDH1A1 | |
| SCHEMBL4846635 | 0.79 | LMNA (0.48) | PTPN1MEN1KMT2ALMNAHPGD | |
| SCHEMBL4848072 | 0.78 | LMNA (0.48) | MEN1KMT2ALMNAHPGDALDH1A1 | |
| SCHEMBL4848487 | 0.77 | LMNA (0.46) | MEN1KMT2ALMNAHPGDALDH1A1 | |
| SCHEMBL4848052 | 0.77 | ABCG2 (0.48) | MEN1KMT2ALMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |