Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.81 |
| ▸ | IGF1R | P08069 | 2/20 | 0.62 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.59 |
| ▸ | TDP2 | O95551 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | CASP9 | P55211 | 1/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852825 | 1.00 | GSK3B (0.81) | GSK3BIGF1RCISD1TDP2CASP7 | |
| SCHEMBL9831864 | 0.89 | GSK3B (1.00) | GSK3BIGF1RCISD1TDP2CASP7 | |
| SCHEMBL9831869 | 0.89 | GSK3B (1.00) | GSK3BIGF1RCISD1TDP2CASP7 | |
| SCHEMBL8308229 | 0.88 | GSK3B (0.82) | GSK3BCISD1RAB9APIM1PIM3 | |
| SCHEMBL6413936 | 0.88 | XDH (0.70) | GSK3BIGF1RCISD1CLK2GSK3A | |
| SCHEMBL6413941 | 0.88 | XDH (0.70) | GSK3BIGF1RCISD1CLK2GSK3A | |
| SCHEMBL8308231 | 0.88 | GSK3B (0.82) | GSK3BCISD1RAB9APIM1PIM3 | |
| SCHEMBL8049587 | 0.85 | GSK3B (0.74) | GSK3BIGF1RCISD1TDP2CASP7 | |
| SCHEMBL8049588 | 0.85 | GSK3B (0.74) | GSK3BIGF1RCISD1TDP2CASP7 | |
| SCHEMBL2882560 | 0.84 | GSK3B (0.68) | GSK3BIGF1RCISD1TDP2CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234020-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP. | 2005-10-20 | — | — | US | claimed |
| EP-1556059-A1 | THROMBOPOIETIN MIMETICS | Smithkline Beecham (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2003103686-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | claimed |
| US-7414040-B2 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-19 | — | — | US | disclosed |
| US-20050234020-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP. | 2005-10-20 | — | — | US | disclosed |
| EP-1556059-A1 | THROMBOPOIETIN MIMETICS | Smithkline Beecham (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003103686-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234020-A1 | Thrombopoietin mimetics | MPL, THPO, TEK | GSK3B 3054/4885IGF1R 269/4885CISD1 2474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.