Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856430 | 1.00 | PTGER1 (0.44) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4856320 | 0.92 | SLC6A9 (0.43) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4854564 | 0.92 | SLC6A9 (0.43) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4850155 | 0.90 | SLC6A9 (0.45) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4852871 | 0.90 | SLC6A9 (0.45) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4855122 | 0.90 | AR (0.48) | BCHEACHEHRH1KDM4EGAA | |
| SCHEMBL4856553 | 0.90 | AR (0.48) | BCHEACHEHRH1KDM4EGAA | |
| SCHEMBL4852981 | 0.89 | SYK (0.42) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4853060 | 0.89 | SYK (0.42) | PTGER1PTGER4PTGER3PTGER2BCHE | |
| SCHEMBL4852994 | 0.88 | PTGER1 (0.45) | PTGER1PTGER4PTGER3PTGER2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |