Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854998 | 0.83 | CYP2D6 (0.60) | GRIN2BPTGS2CYP2D6HIF1AKMT2A | |
| SCHEMBL5595201 | 0.83 | CYP2D6 (0.60) | GRIN2BPTGS2CYP2D6HIF1AKMT2A | |
| SCHEMBL5593828 | 0.82 | PTGS2 (0.45) | GRIN2BPTGS2CYP2D6HIF1APRSS1 | |
| SCHEMBL5594052 | 0.79 | PTGS2 (0.51) | GRIN2BPTGS2CYP2D6HIF1AALDH1A1 | |
| SCHEMBL5698495 | 0.79 | PTGS2 (0.51) | GRIN2BPTGS2PRSS1PRSS2PRSS3 | |
| SCHEMBL5594336 | 0.79 | PTGS2 (0.51) | GRIN2BPTGS2PRSS1PRSS2PRSS3 | |
| SCHEMBL5593941 | 0.79 | PTGS2 (0.51) | GRIN2BPTGS2CYP2D6HIF1AALDH1A1 | |
| SCHEMBL5593964 | 0.78 | MEN1 (0.61) | GRIN2BPTGS2CYP2D6HIF1AKMT2A | |
| SCHEMBL4862318 | 0.78 | KMT2A (0.60) | CYP2D6HIF1AKMT2ALMNAGFER | |
| SCHEMBL8557221 | 0.77 | GRIN2B (0.46) | GRIN2BPTGS2CYP2D6HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259891-A1 | Novel pyrimidon derivatives | TYMS, TPMT, TYMP | GRIN2B 993/4885PTGS2 1957/4885CYP2D6 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.