Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 2/20 | 0.38 |
| ▸ | FNTB | P49356 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874862 | 0.82 | CYP19A1 (0.47) | CYP19A1SMN1; SMN2 | |
| SCHEMBL4701608 | 0.77 | CYP19A1 (0.42) | CYP19A1PARP1FNTAFNTBSIGMAR1 | |
| SCHEMBL4700677 | 0.75 | SYK (0.39) | LMNA | |
| SCHEMBL30874874 | 0.68 | VNN1 (0.44) | — | |
| SCHEMBL474918 | 0.68 | DPP4 (0.57) | ALDH1A1HPGD | |
| SCHEMBL2177077 | 0.68 | DPP4 (0.57) | ALDH1A1HPGD | |
| SCHEMBL30874798 | 0.68 | VNN1 (0.62) | PARP1FNTAFNTBSIGMAR1ALDH1A1 | |
| SCHEMBL4701611 | 0.67 | FNTA (0.53) | CYP19A1FNTAFNTBALDH1A1LMNA | |
| SCHEMBL4705648 | 0.66 | FNTA (0.49) | FNTAFNTBALDH1A1LMNA | |
| SCHEMBL30874864 | 0.66 | VNN1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | claimed |