Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854600 | 0.92 | ALDH1A1 (0.55) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4853398 | 0.91 | KDM4E (0.43) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL2951048 | 0.91 | ALDH1A1 (0.48) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4855936 | 0.91 | ALDH1A1 (0.48) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4864177 | 0.89 | KDM4E (0.49) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4861613 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4855957 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4857021 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4858580 | 0.88 | RXFP1 (0.50) | KDM4EALDH1A1KMT2ARXFP1LMNA | |
| SCHEMBL4854626 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1KMT2ARXFP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | claimed |
| EP-1492774-A2 | PYRIMIDONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOLOGICAL DISEASES | Orchid Chemicals and Pharmaceuticals Ltd (IN) | 2005-01-05 | — | — | EP | claimed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | claimed |
| US-20030225075-A1 | Novel pyrimidone derivatives | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-12-04 | — | — | US | claimed |
| WO-2003084938-A2 | PYRIMIDONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATIN AND IMMUNOLOGICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-10-16 | — | — | WO | claimed |
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| WO-2005091711-A2 | NOVEL CONDENSED PYRIMIDONES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2005-10-06 | — | — | WO | disclosed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | disclosed |
| US-20030225075-A1 | Novel pyrimidone derivatives | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225075-A1 | Novel pyrimidone derivatives | TPMT, TYMP, TYMS | KDM4E 4265/4885ALDH1A1 357/4885KMT2A 4314/4885 |
| US-20040259891-A1 | Novel pyrimidon derivatives | TYMS, TPMT, TYMP | KDM4E 4161/4885ALDH1A1 272/4885KMT2A 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.