Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859624 | 0.90 | PTGS2 (0.46) | KDM4EALDH1A1PTGS2PTGS1 | |
| SCHEMBL6141923 | 0.88 | PTGS2 (0.51) | KDM4EPTGS2PTGS1 | |
| SCHEMBL6141813 | 0.88 | PTGS2 (0.51) | KDM4EPTGS2PTGS1 | |
| SCHEMBL4853028 | 0.88 | KDM4E (0.50) | KDM4EALDH1A1 | |
| SCHEMBL4864987 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1 | |
| SCHEMBL4855004 | 0.86 | PTGS2 (0.41) | KDM4EALDH1A1PTGS2PTGS1 | |
| SCHEMBL6141883 | 0.81 | PTGS2 (0.47) | KDM4EALDH1A1PTGS2PTGS1 | |
| SCHEMBL4861850 | 0.81 | PTGS2 (0.47) | KDM4EALDH1A1PTGS2PTGS1 | |
| SCHEMBL7239883 | 0.79 | PTGS2 (0.47) | KDM4EPTGS2PTGS1 | |
| SCHEMBL6141531 | 0.78 | KMT2A (0.48) | KDM4EALDH1A1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | claimed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | claimed |
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259891-A1 | Novel pyrimidon derivatives | TYMS, TPMT, TYMP | KDM4E 4161/4885ALDH1A1 272/4885PTGS2 1957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.