Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 1.00 |
| ▸ | OPRL1 | P41146 | 10/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4855916 | 0.99 | OPRM1 (1.00) | OPRM1OPRL1EPHX1EPHX2NPC1 | |
| SCHEMBL4858581 | 0.86 | OPRM1 (0.76) | OPRM1OPRL1EPHX1NPC1RAB9A | |
| SCHEMBL4849182 | 0.85 | OPRM1 (0.74) | OPRM1OPRL1EPHX1EPHX2 | |
| Hydrochloric Acid SCHEMBL4852374 | 0.84 | OPRM1 (0.75) | OPRM1OPRL1EPHX1EPHX2 | |
| SCHEMBL2379652 | 0.82 | OPRM1 (0.69) | OPRM1OPRL1EPHX2 | |
| Citric Acid SCHEMBL4861869 | 0.81 | OPRM1 (0.68) | OPRM1OPRL1EPHX1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL302167 | 0.81 | OPRM1 (0.70) | OPRM1OPRL1EPHX2 | |
| SCHEMBL4861071 | 0.80 | OPRM1 (0.67) | OPRM1OPRL1EPHX1EPHX2 | |
| SCHEMBL4955112 | 0.79 | EPHX1 (1.00) | OPRM1OPRL1EPHX1EPHX2NPC1 | |
| SCHEMBL22316228 | 0.79 | EPHX1 (0.73) | OPRM1OPRL1EPHX1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560809-B1 | CYCLOHEXYLUREA DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-08-22 | — | — | EP | claimed |
| US-7348354-B2 | Cyclohexylurea compounds | GRUENENTHAL GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-20050261358-A1 | antinociceptive agent of opioid-receptor for treating pain; tert-aminecyclohexyl-urea, or -thiourea, or -amide derivatives; 1-(4-dimethylamino-4-phenylcyclohexyl)-3-(3-phenylpropyl)urea hydrochloride; stereoisomers; racemic mixtures | GRUENENTHAL GMBH (DE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261358-A1 | antinociceptive agent of opioid-receptor for treating pain; tert-aminecyclohexyl-urea, or -thiourea, or -amide derivatives; 1-(4-dimethylamino-4-phenylcyclohexyl)-3-(3-phenylpropyl)urea hydrochloride; stereoisomers; racemic mixtures | OPRL1, OPRM1, OGFRL1 | OPRM1 2/4885OPRL1 1/4885EPHX1 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.