⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3747628 | 0.84 | LCK (0.50) | — | |
| SCHEMBL6450865 | 0.82 | TDP1 (0.40) | — | |
| SCHEMBL1780149 | 0.80 | — | — | |
| SCHEMBL3825493 | 0.80 | — | — | |
| SCHEMBL8019674 | 0.79 | — | — | |
| SCHEMBL2002867 | 0.78 | — | — | |
| SCHEMBL29244176 | 0.78 | TDP1 (0.41) | — | |
| SCHEMBL9869453 | 0.78 | — | — | |
| SCHEMBL28713719 | 0.75 | ALDH1A1 (0.37) | — | |
| SCHEMBL5197011 | 0.75 | CHRM1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232468-A | A kind of camphorsulfonic acid thiosemicarbazones thiazole compound, preparation method and its application | 南京林业大学 | 2019-01-18 | — | — | CN | claimed |
| CN-109232468-A | A kind of camphorsulfonic acid thiosemicarbazones thiazole compound, preparation method and its application | 南京林业大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-102341379-B | Benzothiazine derivative, its preparation method and the application as medicine thereof | PIERRE FABRE MEDICAMENT (FR) | 2015-08-26 | — | — | CN | disclosed |
| CN-102985411-A | Imaging agents for detecting neurological disorders | SIEMENS MEDICAL SOLUTIONS | 2013-03-20 | — | — | CN | disclosed |
| CN-102341379-A | Derivatives of benzothiazines, preparation thereof and application thereof as drugs | PF MEDICAMENT | 2012-02-01 | — | — | CN | disclosed |
| US-7405221-B2 | Substituted pyrimidines | MERCK & CO., INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-20050245554-A1 | Substituted pyrimidines | MERCK SHARP & DOHME CORP. | 2005-11-03 | — | — | US | disclosed |
| CN-1639146-A | Fused tricyclic heterocycles useful for the treatment of hyperproliferative diseases | BAYER PHARMACEUTICALS CORP (US) | 2005-07-13 | — | — | CN | disclosed |
| EP-1546115-A2 | SUBSTITUTED PYRIMIDINES | Merck & Co., Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004029204-A2 | SUBSTITUTED PYRIMIDINES | MERCK & CO., INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| EP-0877024-B1 | SUBSTITUTED 6-H-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS AN AESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | N T PREDPR LIGAND OBSCHESTVO S (RU) | 2002-02-20 | — | — | EP | disclosed |
| EP-0877024-A1 | SUBSTITUTED 6-H-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS AN AESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | THE PROCTER & GAMBLE COMPANY (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |