Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849180 | 1.00 | MAPT (0.51) | MAPTLMNAKDM4EATMSMN1; SMN2 | |
| SCHEMBL4856209 | 0.94 | MAPT (0.52) | MAPTLMNAKDM4EATMSMN1; SMN2 | |
| SCHEMBL4846123 | 0.94 | MAPT (0.52) | MAPTLMNAKDM4EATMSMN1; SMN2 | |
| SCHEMBL4849185 | 0.88 | PTPN5 (0.53) | MAPTLMNAKDM4EATMSMN1; SMN2 | |
| SCHEMBL4846128 | 0.83 | PTPN5 (0.54) | MAPTLMNAKDM4EATMSMN1; SMN2 | |
| SCHEMBL5915873 | 0.78 | TBXA2R (0.51) | MAPTLMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5915497 | 0.78 | TBXA2R (0.51) | MAPTLMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5915663 | 0.78 | TBXA2R (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1AR | |
| SCHEMBL3684332 | 0.78 | MAPT (0.47) | MAPTLMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3681814 | 0.78 | MAPT (0.47) | MAPTLMNAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |