Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846128 | 0.95 | PTPN5 (0.54) | PTPN5CYSLTR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4849180 | 0.88 | MAPT (0.51) | PTPN5MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4855102 | 0.88 | MAPT (0.51) | PTPN5MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4846123 | 0.83 | MAPT (0.52) | PTPN5MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4856209 | 0.83 | MAPT (0.52) | PTPN5MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11166397 | 0.79 | HTR1B (0.47) | MAPTALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL11166392 | 0.79 | HTR1B (0.47) | MAPTALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL4851312 | 0.78 | PDE4A (0.61) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5915502 | 0.78 | PTPN5 (0.59) | PTPN5MAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5915667 | 0.77 | PTPN5 (0.54) | PTPN5MAPTALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |