Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485934 | 0.98 | CXCR2 (0.47) | CXCR2DRD4MRGPRX4MAPTLMNA | |
| Formic Acid SCHEMBL27693233 | 0.96 | CXCR2 (0.44) | CXCR2DRD4MRGPRX4MAPTLMNA | |
| SCHEMBL485399 | 0.91 | CXCR2 (0.47) | CXCR2DRD4MRGPRX4MAPTLMNA | |
| Bicarbonate SCHEMBL485911 | 0.89 | CXCR2 (0.47) | CXCR2DRD4MRGPRX4MAPTLMNA | |
| Formic Acid SCHEMBL27693241 | 0.88 | CXCR2 (0.44) | CXCR2DRD4MRGPRX4MAPTLMNA | |
| SCHEMBL485699 | 0.85 | CXCR2 (0.62) | CXCR2DRD4MRGPRX4CNR1CNR2 | |
| SCHEMBL485738 | 0.85 | MRGPRX4 (0.51) | DRD4MRGPRX4MAPTLMNAPOLB | |
| Formic Acid SCHEMBL27693419 | 0.85 | MRGPRX4 (0.49) | DRD4MRGPRX4MAPTLMNAPOLB | |
| Bicarbonate SCHEMBL485873 | 0.84 | MRGPRX4 (0.49) | MRGPRX4MAPTLMNAPOLBCRHR1 | |
| Formic Acid SCHEMBL27693221 | 0.84 | KMT2A (0.42) | CXCR2DRD4IDH1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |