Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485567 | 0.98 | CXCR2 (0.47) | CXCR2DRD4MAPTLMNAPOLB | |
| Formic Acid SCHEMBL27693233 | 0.95 | CXCR2 (0.44) | CXCR2DRD4MAPTLMNAPOLB | |
| SCHEMBL485399 | 0.89 | CXCR2 (0.47) | CXCR2DRD4MAPTLMNAPOLB | |
| SCHEMBL485738 | 0.87 | MRGPRX4 (0.51) | DRD4MAPTLMNAPOLBMRGPRX4 | |
| Bicarbonate SCHEMBL485911 | 0.87 | CXCR2 (0.47) | CXCR2DRD4MAPTLMNAPOLB | |
| Formic Acid SCHEMBL27693241 | 0.86 | CXCR2 (0.44) | CXCR2DRD4MAPTLMNAPOLB | |
| Bicarbonate SCHEMBL485873 | 0.86 | MRGPRX4 (0.49) | MAPTLMNAPOLBMRGPRX4NPC1 | |
| SCHEMBL485511 | 0.85 | CXCR2 (0.62) | CXCR2DRD4MRGPRX4CNR1CNR2 | |
| SCHEMBL485699 | 0.84 | CXCR2 (0.62) | CXCR2DRD4MRGPRX4CNR1CNR2 | |
| Formic Acid SCHEMBL27693419 | 0.83 | MRGPRX4 (0.49) | DRD4MAPTLMNAPOLBMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |