Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 11/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197267 | 0.79 | MEN1 (0.56) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL1248947 | 0.77 | PIM1 (0.78) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL1248944 | 0.77 | PIM1 (0.78) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL1248928 | 0.77 | GSK3B (0.64) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL1248930 | 0.77 | GSK3B (0.64) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL4855800 | 0.76 | PIM1 (0.57) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL4857396 | 0.75 | PPARG (0.56) | HPGDMEN1KMT2APPARG | |
| SCHEMBL1247708 | 0.74 | PIM1 (1.00) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL1247705 | 0.74 | PIM1 (1.00) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL2546911 | 0.74 | PIM1 (1.00) | PIM1PIM2AKR1B1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050159463-A1 | Indole derivatives | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2005-07-21 | — | — | US | claimed |
| EP-1189583-B1 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2005-07-20 | — | — | EP | claimed |
| EP-1189583-A4 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2004-04-14 | — | — | EP | claimed |
| EP-1189583-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LIMITED (IL) | 2002-03-27 | — | — | EP | claimed |
| WO-2000072815-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2000-12-07 | — | — | WO | claimed |
| US-7355054-B2 | Indole derivatives | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2008-04-08 | — | — | US | disclosed |
| US-20050159463-A1 | Indole derivatives | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2005-07-21 | — | — | US | disclosed |
| EP-1189583-B1 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2005-07-20 | — | — | EP | disclosed |
| US-6858642-B1 | Indole derivatives | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2005-02-22 | — | — | US | disclosed |
| EP-1189583-A4 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2004-04-14 | — | — | EP | disclosed |
| EP-1189583-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LIMITED (IL) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000072815-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2000-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159463-A1 | Indole derivatives | IDO1, IDO2, H1-0 | PIM1 3614/4885PIM2 3451/4885AKR1B1 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.