Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12990370 | 0.85 | PTGDR2 (0.55) | PTGDR2KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL4846536 | 0.83 | CYP1A2 (0.53) | KDM4EALDH1A1TDP1ADRB2ADRB1 | |
| SCHEMBL5699880 | 0.82 | HPGD (0.65) | PTGDR2KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL30304109 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1ADRB2ADRB1HTR7 | |
| SCHEMBL29189194 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1ADRB2ADRB1HTR7 | |
| SCHEMBL30304134 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1LMNAADRB2ADRB1 | |
| SCHEMBL29189171 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1LMNAADRB2ADRB1 | |
| SCHEMBL12293415 | 0.81 | PTGDR2 (0.60) | PTGDR2KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL29888853 | 0.81 | PTGDR2 (0.60) | PTGDR2KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL4960450 | 0.81 | PTGDR2 (0.60) | PTGDR2KDM4EALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | LICA PHARMACEUTICALS A/S (DK) | 2008-01-31 | — | — | US | disclosed |
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | LICA PHARMACEUTICALS A/S (DK) | 2008-01-31 | — | — | US | disclosed |
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | LICA PHARMACEUTICALS A/S (DK) | 2008-01-31 | — | — | US | disclosed |
| EP-1682486-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2006-07-26 | — | — | EP | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |
| WO-2005042467-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2005-05-12 | — | — | WO | disclosed |
| EP-1515940-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003097574-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | NR2E1, BET1, NR0B1 | PTGDR2 3001/4885KDM4E 747/4885ALDH1A1 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.