Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485687 | 0.87 | MRGPRX4 (0.45) | MAPTLMNAPOLBHCRTR1SCN7A | |
| SCHEMBL485511 | 0.86 | CXCR2 (0.62) | CXCR2DRD4MRGPRX4CNR1CNR2 | |
| SCHEMBL485826 | 0.86 | MRGPRX4 (0.51) | MAPTLMNAPOLBHCRTR1MRGPRX4 | |
| SCHEMBL485799 | 0.85 | MRGPRX4 (0.45) | MAPTLMNAPOLBHCRTR1SCN7A | |
| SCHEMBL485699 | 0.84 | CXCR2 (0.62) | CXCR2DRD4MRGPRX4CNR1CNR2 | |
| Formic Acid SCHEMBL27693250 | 0.83 | MRGPRX4 (0.43) | MAPTLMNAPOLBHCRTR1SCN7A | |
| SCHEMBL485934 | 0.82 | CXCR2 (0.47) | CXCR2DRD4MAPTLMNAPOLB | |
| SCHEMBL485472 | 0.82 | CXCR2 (0.56) | CXCR2HCRTR1RAB9AALOX5AP | |
| SCHEMBL485579 | 0.81 | CXCR2 (0.47) | CXCR2DRD4MAPTRAB9ACNR1 | |
| Formic Acid SCHEMBL27713047 | 0.81 | CXCR2 (0.58) | CXCR2DRD4MRGPRX4CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |