Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14419271 | 0.89 | GAA (0.54) | GAAALPLCYP19A1SMN1; SMN2MAPK1 | |
| SCHEMBL25263951 | 0.84 | GAA (0.50) | GAAALPLSMN1; SMN2MAPK1KDM4E | |
| SCHEMBL10562484 | 0.84 | ALPL (0.45) | ALPLCYP19A1MAPK1KMT2AKDM4E | |
| SCHEMBL25262647 | 0.83 | GAA (0.67) | GAACYP19A1SMN1; SMN2MAPK1KDM4E | |
| Hydrochloric Acid SCHEMBL30231158 | 0.83 | GAA (0.49) | GAACYP19A1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10967991 | 0.81 | SMN1; SMN2 (0.53) | GAACYP19A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL10968819 | 0.79 | SLC6A4 (0.48) | GAACYP19A1SMN1; SMN2KMT2AHSP90AA1 | |
| SCHEMBL11196051 | 0.75 | GAA (0.41) | GAACYP19A1SMN1; SMN2SLC6A4CYP3A4 | |
| SCHEMBL10705171 | 0.74 | SMN1; SMN2 (0.56) | GAASMN1; SMN2MAPK1KMT2AKDM4E | |
| SCHEMBL10970695 | 0.74 | SMN1; SMN2 (0.46) | CYP19A1SMN1; SMN2MAPK1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | GAA 1745/4885ALPL 4020/4885CYP19A1 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.