Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL27713056 | 0.95 | ALOX5AP (0.48) | ALOX5APGAAKMT2ACNR1CNR2 | |
| Formic Acid SCHEMBL27693208 | 0.85 | ALOX5AP (0.51) | ALOX5APGAAKMT2ACNR1CNR2 | |
| SCHEMBL485800 | 0.81 | KMT2A (0.49) | GAAKMT2ARAB9AALOX5SMN1; SMN2 | |
| SCHEMBL485826 | 0.81 | MRGPRX4 (0.51) | GAAKMT2ALMNAMAPT | |
| SCHEMBL485373 | 0.81 | CXCR2 (0.47) | ALOX5AP | |
| SCHEMBL485362 | 0.81 | CXCR2 (0.49) | ALOX5APKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL27713055 | 0.80 | ALOX5AP (0.44) | ALOX5APKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL485638 | 0.79 | KDM4E (0.53) | ALOX5APKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL485827 | 0.79 | MAOB (0.47) | ALOX5APKMT2ACNR1CNR2RAB9A | |
| Bicarbonate SCHEMBL485659 | 0.77 | ALOX5 (0.48) | ALOX5APKMT2ARAB9AALOX5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |