Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10774544 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL10618514 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL10620628 | 0.75 | TSHR (0.42) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL31267359 | 0.74 | KDM4E (0.53) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL7220081 | 0.73 | MAPT (0.52) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL31143068 | 0.71 | PDE4A (0.40) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL7228171 | 0.71 | KDM4E (0.56) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8050780 | 0.70 | MEN1 (0.55) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL4852334 | 0.70 | KDM4E (0.45) | ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL23460007 | 0.69 | MEN1 (0.57) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-20060041003-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME LLC | 2006-02-23 | — | — | US | disclosed |
| EP-1551820-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1522342-A1 | PHOTOCATALYST EXHIBITING CATALYTIC ACTIVITY EVEN IN VISIBLE LIGHT REGION | SUMITOMO METAL MINING COMPANY LIMITED (JP) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004026887-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20030144140-A1 | Photocatalyst exhibiting catalytic activity even in visible light region | SUMITOMO METAL MINING CO., LTD. (JP) | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041003-A1 | Estrogen receptor modulators | GPER1, ESR2, ESR1 | ALDH1A1 1646/4885KDM4E 1225/4885KMT2A 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.