Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867900 | 0.82 | TGFBR1 (0.56) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4860157 | 0.81 | TGFBR1 (0.43) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4866086 | 0.80 | TGFBR1 (0.56) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4860805 | 0.78 | TGFBR1 (0.57) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4859601 | 0.78 | MAPK14 (0.44) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4863569 | 0.77 | MAPK14 (0.59) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4863393 | 0.72 | TGFBR1 (0.55) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4868497 | 0.71 | TGFBR1 (0.60) | TGFBR1MAPK14 | |
| SCHEMBL412627 | 0.70 | MAPK14 (0.55) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4038621 | 0.70 | TGFBR1 (0.40) | TGFBR1MAPK14CYP2D6TGFBR2MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417041-B2 | Imidazopyrimidines as transforming growth factor (TGF) inhibitors | PFIZER INC. (US) | 2008-08-26 | — | — | US | claimed |