Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | STK36 | Q9NRP7 | 1/20 | 0.47 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14003196 | 0.90 | MAPK8 (0.59) | MAPK14MAPK8MAPK9MAPK10GAK | |
| SCHEMBL5260841 | 0.86 | MAPK14 (0.60) | MAPK14MAPK8MAPK9MAPK10GAK | |
| SCHEMBL14457338 | 0.85 | MAPK8 (0.52) | MAPK14MAPK8MAPK9MAPK10GAK | |
| SCHEMBL14003195 | 0.82 | MAPK8 (0.67) | MAPK14MAPK8MAPK9MAPK10GAK | |
| SCHEMBL4859569 | 0.81 | MAPK8 (0.69) | MAPK14MAPK8MAPK9MAPK10GAK | |
| SCHEMBL14003166 | 0.79 | MAPK14 (0.55) | MAPK14MAPK8MAP4K4 | |
| SCHEMBL559211 | 0.78 | MAPK8 (0.54) | MAPK14MAPK8MAPK9MAPK10LCK | |
| SCHEMBL559210 | 0.78 | MAPK8 (0.54) | MAPK14MAPK8MAPK9MAPK10LCK | |
| SCHEMBL14014642 | 0.75 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10GAK | |
| SCHEMBL4860231 | 0.73 | SCN9A (0.46) | MAPK14MAPK8MAPK9MAPK10RPS6KA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456185-B2 | Substituted quinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070167471-A1 | Substituted quinazoline compounds useful as p38 kinase inhibitors | DUNN JAMES P | 2007-07-19 | — | — | US | disclosed |
| US-7238698-B2 | Substituted quinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167471-A1 | Substituted quinazoline compounds useful as p38 kinase inhibitors | MAPK1, MAPK7, MAPK3 | MAPK14 12/4885MAPK8 5/4885MAPK9 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.