Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.55 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CDK4 | P11802 | 3/20 | 0.51 |
| ▸ | CCND1 | P24385 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.51 |
| ▸ | CDK7 | P50613 | 4/20 | 0.51 |
| ▸ | CCNH | P51946 | 4/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.51 |
| ▸ | CCNK | O75909 | 3/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855986 | 0.85 | NOS2 (0.61) | MAPK8CDK2CDK1CDK4CCND1 | |
| SCHEMBL14003195 | 0.83 | MAPK8 (0.67) | MAPK8MAPK14CDK2CDK1CDK4 | |
| SCHEMBL5114582 | 0.81 | MAPK8 (1.00) | MAPK8MAPK14GAKRPS6KA4PRKD3 | |
| SCHEMBL4858175 | 0.81 | MAPK14 (0.60) | MAPK8MAPK14GAKRPS6KA4PRKD3 | |
| SCHEMBL14003196 | 0.81 | MAPK8 (0.59) | MAPK8MAPK14GAKRPS6KA4PRKD3 | |
| SCHEMBL3067448 | 0.79 | BRAF (0.57) | — | |
| SCHEMBL14457338 | 0.79 | MAPK8 (0.52) | MAPK8MAPK14GAKRPS6KA4PRKD3 | |
| SCHEMBL23063748 | 0.78 | CDK7 (0.62) | MAPK8CDK2CCNA2CDK7CCNH | |
| SCHEMBL14014477 | 0.75 | MAPK8 (0.88) | MAPK8MAPK14GAKRPS6KA4PRKD3 | |
| SCHEMBL30335907 | 0.74 | MAPK8 (0.87) | MAPK8MAPK14CDK2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456185-B2 | Substituted quinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070167471-A1 | Substituted quinazoline compounds useful as p38 kinase inhibitors | DUNN JAMES P | 2007-07-19 | — | — | US | disclosed |
| US-7238698-B2 | Substituted quinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167471-A1 | Substituted quinazoline compounds useful as p38 kinase inhibitors | MAPK1, MAPK7, MAPK3 | MAPK8 5/4885MAPK14 12/4885CDK2 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.