Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | PPIB | P23284 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857308 | 0.90 | SMN1; SMN2 (0.46) | METAP1SMN1; SMN2CYP24A1MPOESR1 | |
| SCHEMBL6860603 | 0.89 | METAP1 (0.47) | METAP1SMN1; SMN2CA1CA2CA4 | |
| SCHEMBL9956484 | 0.84 | SMN1; SMN2 (0.39) | METAP1SMN1; SMN2CYP24A1CA1CA2 | |
| SCHEMBL6855815 | 0.84 | METAP1 (0.43) | METAP1SMN1; SMN2CA1CA2CA4 | |
| SCHEMBL4856946 | 0.82 | SMN1; SMN2 (0.43) | METAP1SMN1; SMN2CA1CA2CA4 | |
| SCHEMBL2419171 | 0.81 | BACE1 (0.44) | METAP1SMN1; SMN2CA1CA2CA4 | |
| SCHEMBL6862389 | 0.81 | METAP1 (0.44) | METAP1SMN1; SMN2CA1CA2CA4 | |
| SCHEMBL2417911 | 0.81 | BACE1 (0.43) | METAP1SMN1; SMN2CA1CA2CA4 | |
| SCHEMBL629836 | 0.80 | SMN1; SMN2 (0.53) | METAP1SMN1; SMN2CYP24A1MPOPRNP | |
| SCHEMBL4853241 | 0.80 | SMN1; SMN2 (0.50) | METAP1SMN1; SMN2CYP24A1MPOPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-20060041003-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME LLC | 2006-02-23 | — | — | US | disclosed |
| EP-1551820-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026887-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041003-A1 | Estrogen receptor modulators | GPER1, ESR2, ESR1 | METAP1 3319/4885SMN1; SMN2 1753/4885CYP24A1 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.