Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PPIB | P23284 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.34 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859451 | 0.84 | METAP1 (0.40) | SMN1; SMN2METAP1BACE1CA1CA2 | |
| SCHEMBL4856946 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2METAP1BACE1CA1CA2 | |
| SCHEMBL2419171 | 0.82 | BACE1 (0.44) | SMN1; SMN2METAP1BACE1CA1CA2 | |
| SCHEMBL2417911 | 0.81 | BACE1 (0.43) | SMN1; SMN2METAP1BACE1CA1CA2 | |
| SCHEMBL21553806 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2METAP1CA1CA2CA4 | |
| SCHEMBL6855815 | 0.78 | METAP1 (0.43) | SMN1; SMN2METAP1BACE1CA1CA2 | |
| SCHEMBL4857308 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2METAP1MPOESR1ESR2 | |
| SCHEMBL4857128 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2CA1CA2CA4CA7 | |
| SCHEMBL6862389 | 0.74 | METAP1 (0.44) | SMN1; SMN2METAP1BACE1CA1CA2 | |
| SCHEMBL6860603 | 0.74 | METAP1 (0.47) | SMN1; SMN2METAP1CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655431-A1 | BRIDGED METALLOCENE CATALYSTS | Borealis AG (AT) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012084961-A1 | BRIDGED METALLOCENE CATALYSTS | BOREALIS AG (AT) | 2012-06-28 | — | — | WO | disclosed |