Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 18/20 | 0.81 |
| ▸ | ESR1 | P03372 | 17/20 | 0.81 |
| ▸ | PRNP | P04156 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2413158 | 0.89 | ESR2 (1.00) | ESR2ESR1PRNP | |
| SCHEMBL4858834 | 0.85 | ESR2 (0.80) | ESR2ESR1PRNPMAOAMAOB | |
| SCHEMBL4850670 | 0.81 | ESR2 (0.82) | ESR2ESR1 | |
| SCHEMBL4856461 | 0.79 | ESR2 (0.83) | ESR2ESR1 | |
| SCHEMBL4850382 | 0.77 | ESR2 (0.83) | ESR2ESR1 | |
| SCHEMBL2418508 | 0.77 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL4858204 | 0.76 | ESR1 (0.54) | ESR2ESR1PRNP | |
| SCHEMBL4853909 | 0.73 | ESR2 (0.85) | ESR2ESR1 | |
| SCHEMBL2417699 | 0.71 | PRNP (0.81) | ESR2ESR1PRNP | |
| SCHEMBL3050076 | 0.70 | MAOA (0.50) | ESR2ESR1MAOAMAOBPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | claimed |
| US-20060041003-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME LLC | 2006-02-23 | — | — | US | claimed |
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-20060041003-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME LLC | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041003-A1 | Estrogen receptor modulators | GPER1, ESR2, ESR1 | ESR2 2/4885ESR1 3/4885PRNP 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.