Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514511 | 0.85 | GPR119 (0.73) | GPR119NAMPTDDB1CRBNSTS | |
| SCHEMBL4519083 | 0.84 | GPR119 (0.76) | GPR119NAMPT | |
| SCHEMBL4183357 | 0.81 | GPR119 (0.57) | GPR119NAMPTDDB1CRBNSTS | |
| SCHEMBL18379198 | 0.81 | GPR119 (0.62) | GPR119NAMPTDDB1CRBNSTS | |
| SCHEMBL3854559 | 0.80 | NAMPT (0.61) | GPR119NAMPTDDB1CRBNSTS | |
| SCHEMBL12117456 | 0.80 | GPR119 (0.65) | GPR119NAMPTDDB1CRBNKDM4E | |
| SCHEMBL12321681 | 0.79 | NAMPT (0.60) | GPR119NAMPTDDB1CRBNSTS | |
| SCHEMBL18805528 | 0.79 | NAMPT (0.60) | GPR119NAMPTDDB1CRBNKDM4E | |
| SCHEMBL2594236 | 0.79 | NAMPT (0.60) | GPR119NAMPTDDB1CRBNKDM4E | |
| SCHEMBL270733 | 0.79 | NAMPT (0.60) | GPR119NAMPTDDB1CRBNSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909791-A1 | G-PROTEIN COUPLED RECEPTOR AGONISTS | Prosidion Limited (GB) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007003964-A1 | G-PROTEIN COUPLED RECEPTOR AGONISTS | PROSIDION LIMITED (GB) | 2007-01-11 | — | — | WO | disclosed |