Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329208 | 0.90 | C5AR1 (0.41) | GRM5S1PR1RAB9ANPC1MAPT | |
| SCHEMBL1327918 | 0.79 | C5AR1 (0.45) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1329718 | 0.77 | GRM5 (0.42) | GRM5RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1328649 | 0.76 | RXRA (0.43) | MRGPRX4C5AR1RXRARXRBRXRG | |
| SCHEMBL1329407 | 0.75 | C5AR1 (0.38) | RAB9ANPC1MAPTL3MBTL1MEN1 | |
| SCHEMBL1327238 | 0.75 | C5AR1 (0.40) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1327672 | 0.74 | C5AR1 (0.39) | MAPTSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL1328738 | 0.73 | C5AR1 (0.39) | RAB9ANPC1MAPTHTTNPSR1 | |
| SCHEMBL1329519 | 0.73 | C5AR1 (0.38) | S1PR1MAPTSMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL1329454 | 0.73 | FFAR1 (0.38) | MAPTHTTC5AR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | claimed |