SCHEMBL4860709

SCHEMBL4860709

FC(F)(F)C(OC(Cl)Cl)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL809377 0.78 CA1 (0.38) MEN1KMT2ACA1CA2CA9
SCHEMBL20198131 0.75 MEN1 (0.38) MEN1KMT2AALDH1A1HSD17B10
SCHEMBL6548087 0.74 CA1 (0.36) MEN1KMT2ACA1CA2CA9
SCHEMBL20980042 0.72 CA1 (0.35) MEN1KMT2ACA1CA2CA9
SCHEMBL3013709 0.71 MEN1 (0.46) MEN1KMT2AALDH1A1HSD17B10
SCHEMBL4596209 0.69 MEN1 (0.50) MEN1KMT2ACA1CA2CA9
SCHEMBL8574969 0.67 MEN1 (0.42) MEN1KMT2AALDH1A1HSD17B10
SCHEMBL19214403 0.67 CA1 (0.32) CA1CA2CA9
SCHEMBL108836 0.67 CA1 (0.32) CA1CA2CA9
SCHEMBL30956645 0.67 MEN1 (0.35) MEN1KMT2ACA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1583727-B1 PROCESS FOR RECOVERY OF 1,1,1,3,3,3-HEXAFLUOROISOPROPANOL FROM THE WASTE STREAM OF SEVOFLURANE SYNTHESIS BAXTER INT INC (A DELAWARE CORPORATION) (US) 2017-03-15 EP claimed
EP-1583727-B1 PROCESS FOR RECOVERY OF 1,1,1,3,3,3-HEXAFLUOROISOPROPANOL FROM THE WASTE STREAM OF SEVOFLURANE SYNTHESIS BAXTER INT INC (A DELAWARE CORPORATION) (US) 2017-03-15 EP disclosed
US-7375254-B2 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis BAXTER INTERNATIONAL INC. (US) 2008-05-20 US disclosed
US-7375254-B2 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis BAXTER INTERNATIONAL INC. (US) 2008-05-20 US disclosed
US-6987204-B2 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis BAXTER INTERNATIONAL INC. (US) 2006-01-17 US disclosed
EP-1583727-A1 PROCESS FOR RECOVERY OF 1,1,1,3,3,3-HEXAFLUOROISOPROPANOL FROM THE WASTE STREAM OF SEVOFLURANE SYNTHESIS BAXTER INTERNATIONAL INC. (a Delaware corporation) (US) 2005-10-12 EP disclosed
US-20050222468-A1 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis BAXTER INTERNATIONAL INC. 2005-10-06 US disclosed
WO-2004065340-A1 PROCESS FOR RECOVERY OF 1,1,1,3,3,3-HEXAFLUOROISOPROPANOL FROM THE WASTE STREAM OF SEVOFLURANE SYNTHESIS BAXTER INTERNATIONAL INC. (US) 2004-08-05 WO disclosed
US-20040147779-A1 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis BAXTER INTERNATIONAL INC 2004-07-29 US disclosed
EP-0830436-A1 REFRIGERANTS BASED ON HYDROFLUOROETHER OF FLUOROETHER E.I. DU PONT DE NEMOURS & CO. (INC.) (US) 1998-03-25 EP disclosed
WO-1996040834-A1 REFRIGERANTS BASED ON HYDROFLUOROETHER OF FLUOROETHER E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050222468-A1 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis PFDN2, HIRIP3, PFDN1 MEN1 4323/4885KMT2A 2207/4885ALDH1A1 2777/4885
US-20040147779-A1 Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis PFDN2, HAO2, PUM2 MEN1 4648/4885KMT2A 2251/4885ALDH1A1 3093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.