Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.48 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28207999 | 0.89 | KDM4E (0.60) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL27347975 | 0.88 | KDM4E (0.58) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL2931171 | 0.87 | KDM4E (0.71) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL22529432 | 0.85 | KDM4E (0.69) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL6518676 | 0.84 | KDM4E (0.71) | KDM4EKMT2AGAAMAPTIDO1 | |
| Trifluoroacetic Acid SCHEMBL27758366 | 0.83 | KDM4E (0.66) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL27758363 | 0.82 | KDM4E (0.64) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL384385 | 0.81 | KDM4E (0.74) | KDM4EKMT2AGAAMAPTIDO1 | |
| SCHEMBL1429381 | 0.80 | PDGFRB (0.77) | KDM4EKMT2APDGFRBPDGFRAFLT3 | |
| SCHEMBL29540321 | 0.80 | PDGFRB (0.77) | KDM4EKMT2APDGFRBPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118666945-A | Metabolic stable anti-drug-resistant main protease inhibitor and application thereof in preparing antiviral drugs | 上海市重大传染病和生物安全研究院 | 2024-09-20 | — | — | CN | disclosed |
| US-7342030-B2 | Indole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1797086-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006032509-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |
| US-20060063812-A1 | Indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063812-A1 | Indole derivatives | IDO1, IDO2, TPH1 | KDM4E 2940/4885KMT2A 2959/4885GAA 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.