Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 known ✓ | P04626 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 9/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14240058 | 0.91 | EGFR (0.45) | CNR2ALDH1A1CYP2C9EGFRERBB2 | |
| SCHEMBL10953695 | 0.85 | CNR2 (0.54) | CNR2MCHR1CNR1ALDH1A1TSHR | |
| SCHEMBL17660036 | 0.84 | EGFR (0.42) | CNR2MCHR1ALDH1A1EGFRERBB2 | |
| SCHEMBL17660030 | 0.84 | EGFR (0.42) | CNR2MCHR1ALDH1A1EGFRERBB2 | |
| SCHEMBL17660035 | 0.84 | EGFR (0.42) | CNR2MCHR1ALDH1A1EGFRERBB2 | |
| SCHEMBL15682788 | 0.84 | EGFR (0.42) | CNR2MCHR1ALDH1A1EGFRERBB2 | |
| SCHEMBL5874555 | 0.83 | MCHR1 (0.58) | CNR2MCHR1PSEN1PSEN2APH1B | |
| SCHEMBL17705087 | 0.82 | POLB (0.50) | CNR2ALDH1A1CYP2C9EGFRERBB2 | |
| SCHEMBL16566787 | 0.82 | POLB (0.50) | CNR2ALDH1A1CYP2C9EGFRERBB2 | |
| Hexane SCHEMBL7122950 | 0.81 | MCHR1 (0.53) | CNR2MCHR1ALDH1A1CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496375-B1 | Composition for optical film comprising a near-infrared absorbing dye and a quencher | ASAHI GLASS CO LTD (JP) | 2008-10-15 | — | — | EP | disclosed |
| US-7332257-B2 | Composition for optical film, and optical film | ASAHI GLASS COMPANY, LIMITED (JP) | 2008-02-19 | — | — | US | disclosed |
| US-20050008969-A1 | Composition for optical film, and optical film | ASAHI GLASS COMPANY, LIMITED (JP) | 2005-01-13 | — | — | US | disclosed |
| EP-1496375-A2 | Composition for optical film comprising a near-infrared absorbing dye and a quencher | Asahi Glass Co., Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |