Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | C1R | P00736 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11404242 | 1.00 | MAPK1 (0.59) | MAPK1ALDH1A1GRM2KMT2AFFAR1 | |
| Bicarbonate SCHEMBL27489215 | 0.87 | ALDH1A1 (0.81) | MAPK1ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL31295703 | 0.85 | ALDH1A1 (0.67) | MAPK1ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL358976 | 0.85 | ALDH1A1 (0.67) | MAPK1ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL5099606 | 0.84 | KMT2A (0.64) | MAPK1ALDH1A1KMT2ALMNAHTT | |
| SCHEMBL11816433 | 0.84 | ALDH1A1 (0.48) | MAPK1ALDH1A1GRM2KMT2AFFAR1 | |
| SCHEMBL7519287 | 0.82 | ALDH1A1 (0.63) | MAPK1ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL31465796 | 0.82 | ALDH1A1 (0.63) | MAPK1ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL28368379 | 0.80 | KMT2A (0.47) | MAPK1ALDH1A1GRM2KMT2AMEN1 | |
| Bromide SCHEMBL6343983 | 0.79 | ALDH1A1 (0.60) | MAPK1ALDH1A1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7471360-B2 | Liquid crystal display device | KONICA MINOLTA OPTO, INC. (JP) | 2008-12-30 | — | — | US | disclosed |
| US-20070046870-A1 | Liquid crystal display device | KONICA MINOLTA OPTO, INC. | 2007-03-01 | — | — | US | disclosed |