Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.73 |
| ▸ | CDK2 | P24941 | 15/20 | 0.70 |
| ▸ | CDK1 | P06493 | 7/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CDKL1 | Q00532 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924704 | 0.90 | KCNH2 (0.82) | KCNH2CDK2CDK1CDK4CDKL1 | |
| SCHEMBL2926867 | 0.85 | KCNH2 (0.77) | KCNH2CDK2CDK1CDK4CDKL1 | |
| SCHEMBL27382932 | 0.84 | CDK2 (0.83) | KCNH2CDK2CDK1 | |
| SCHEMBL30828143 | 0.84 | CDK2 (0.83) | KCNH2CDK2CDK1 | |
| Lithium Ion SCHEMBL2924705 | 0.83 | KCNH2 (0.81) | KCNH2CDK2CDK1CDK4CDKL1 | |
| SCHEMBL1447527 | 0.83 | CDK2 (0.81) | KCNH2CDK2CDK1 | |
| SCHEMBL4516321 | 0.83 | CDK2 (1.00) | KCNH2CDK2CDK1CDK4CDKL1 | |
| SCHEMBL2924335 | 0.81 | CDK2 (0.81) | KCNH2CDK2CDK1CDK4CDKL1 | |
| SCHEMBL2925264 | 0.80 | CDK2 (1.00) | KCNH2CDK2CDK1CDK4CDKL1 | |
| SCHEMBL1447285 | 0.80 | CDK2 (0.76) | KCNH2CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912974-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015064-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | WO | disclosed |