Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL486397 | 0.90 | CASP3 (0.35) | MAP2K1MAP2K2DAOCASP3NOX4 | |
| SCHEMBL4142105 | 0.88 | NPSR1 (0.36) | DAONOX4MAPK13MAPK12MAPK11 | |
| SCHEMBL27093435 | 0.86 | MAP2K1 (0.38) | MAP2K1MAP2K2MAP2K5EIF2AK1CASP3 | |
| SCHEMBL486648 | 0.82 | CASP3 (0.35) | MAP2K1MAP2K2DAOCASP3NOX4 | |
| SCHEMBL13063584 | 0.76 | MAP2K1 (0.35) | MAP2K1MAP2K2MAP2K5EIF2AK1NOX4 | |
| SCHEMBL14257399 | 0.75 | ATM (0.44) | MAP2K1MAP2K2CASP3MAPK13MAPK12 | |
| SCHEMBL1516498 | 0.75 | CASP3 (0.36) | MAP2K1MAP2K2DAOCASP3NOX4 | |
| SCHEMBL13063820 | 0.73 | MAP2K1 (0.32) | MAP2K1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL487093 | 0.71 | MAP2K1 (0.39) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL31487922 | 0.71 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411366-B1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2015-05-20 | — | — | EP | disclosed |
| EP-2411366-B1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-8673919-B2 | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673919-B2 | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20120107307-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2411366-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | Ardea Biosciences, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108652-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010108652-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107307-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | BRAF, NRAS, MAP3K12 | MAP2K1 59/4885MAP2K2 52/4885MAP2K5 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.