Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 16/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367891 | 0.80 | NR1H2 (0.75) | NR1H2NR1H3 | |
| SCHEMBL13663125 | 0.79 | CYP1A2 (0.49) | NR1H2NR1H3CKS1BSKP1SKP2 | |
| SCHEMBL12450000 | 0.78 | HSP90AA1 (0.52) | NR1H2NR1H3BCHEGPR119CKS1B | |
| SCHEMBL26984205 | 0.77 | BCHE (0.44) | NR1H2NR1H3BCHEGPR119CKS1B | |
| SCHEMBL4727654 | 0.76 | NR1H2 (0.50) | NR1H2NR1H3 | |
| SCHEMBL4726985 | 0.76 | NR1H2 (0.50) | NR1H2NR1H3 | |
| SCHEMBL17220693 | 0.76 | NR1H2 (0.61) | NR1H2NR1H3 | |
| SCHEMBL17220666 | 0.76 | NR1H2 (0.59) | NR1H2NR1H3 | |
| SCHEMBL31282282 | 0.76 | NR1H2 (0.59) | NR1H2NR1H3 | |
| SCHEMBL8820122 | 0.76 | NR1H2 (0.62) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423059-B2 | Pharmaceutically active compounds and methods of use | WYETH (US) | 2008-09-09 | — | — | US | disclosed |
| US-7423059-B2 | Pharmaceutically active compounds and methods of use | WYETH (US) | 2008-09-09 | — | — | US | disclosed |