Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17087998 | 0.80 | ELANE (0.53) | ELANEALDH1A1MAOAMAOB | |
| SCHEMBL25054976 | 0.80 | ELANE (0.53) | ELANEALDH1A1MAPTTSHRTDP1 | |
| SCHEMBL18347797 | 0.80 | ELANE (0.43) | ELANEACHEALDH1A1KMT2AMAPT | |
| SCHEMBL23478802 | 0.79 | ELANE (0.51) | ELANETSHRKDM4EPOLBHPGD | |
| SCHEMBL16879802 | 0.77 | ELANE (0.50) | ELANEALDH1A1KMT2AMAPTGAA | |
| SCHEMBL4310699 | 0.77 | DHODH (0.56) | ELANEALDH1A1RAB9AKMT2AMAPT | |
| SCHEMBL31748848 | 0.76 | ELANE (0.49) | ELANEALDH1A1RAB9AKMT2AMAPT | |
| SCHEMBL2045577 | 0.76 | ALDH1A1 (0.48) | ELANEACHEALDH1A1RAB9AKMT2A | |
| SCHEMBL17914088 | 0.75 | ELANE (0.51) | ELANEALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL10236256 | 0.74 | NPC1 (0.48) | ALDH1A1RAB9AKMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411526-A2 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | Zacharon Pharmaceuticals, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111711-A2 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |