Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878206 | 1.00 | ALOX5 (0.49) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL4876526 | 0.91 | ALOX5 (0.43) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL4876492 | 0.91 | ALOX5 (0.43) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL4869711 | 0.86 | PIK3CD (0.43) | ALOX5CLK1PIK3CDPIM1CSNK2A2 | |
| SCHEMBL4864070 | 0.81 | CDK1 (0.46) | ALOX5CLK1PIK3CDPIM1CSNK2A2 | |
| SCHEMBL4867293 | 0.81 | ALOX5 (0.48) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL4876300 | 0.80 | PIK3CD (0.52) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL2990597 | 0.80 | ALOX5 (0.55) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL2990591 | 0.80 | ALOX5 (0.55) | ALOX5CYP3A4CLK1PIK3CDPIM1 | |
| SCHEMBL4871523 | 0.79 | PIK3CD (0.55) | ALOX5CYP3A4CLK1PIK3CDPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-20060004045-A1 | Thiazolinone unsubstituted quinolines | CHEN LI | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004045-A1 | Thiazolinone unsubstituted quinolines | CDK1, CDK17, CDK14 | ALOX5 4785/4885CYP3A4 2710/4885CLK1 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.