Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246229 | 0.84 | HCRTR2 (0.49) | TSHRALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL3256243 | 0.83 | ALDH1A1 (0.63) | TSHRALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL3247471 | 0.81 | TSHR (0.52) | TSHRALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL3247678 | 0.80 | TSHR (0.53) | TSHRALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL3250762 | 0.80 | MAPT (0.53) | TSHRALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL3252098 | 0.79 | TSHR (0.49) | TSHRALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL3247755 | 0.79 | MAPK1 (0.59) | TSHRALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3253821 | 0.78 | MAPK1 (0.50) | TSHRALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3253343 | 0.78 | ALDH1A1 (0.49) | TSHRALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4863480 | 0.78 | ALDH1A1 (0.53) | TSHRALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396958-B2 | Sulphonamide derivatives, their preparation and their therapeutic application | SANOFI AVENTIS (FR) | 2008-07-08 | — | — | US | disclosed |