⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677084 | 0.93 | — | — | |
| SCHEMBL36310 | 0.90 | CYP2C19 (0.44) | — | |
| SCHEMBL11006083 | 0.88 | CYP2C19 (0.42) | — | |
| SCHEMBL198365 | 0.86 | — | — | |
| SCHEMBL5402819 | 0.71 | — | — | |
| SCHEMBL8907359 | 0.69 | FFAR3 (0.40) | — | |
| SCHEMBL127199 | 0.69 | FFAR3 (0.40) | — | |
| Hydrochloric Acid SCHEMBL627730 | 0.69 | FFAR3 (0.40) | — | |
| SCHEMBL20679 | 0.69 | FFAR3 (0.40) | — | |
| Hydrochloric Acid SCHEMBL2294530 | 0.69 | FFAR3 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3870295-B1 | NOVEL TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2023-03-08 | — | — | EP | claimed |
| US-20220402897-A1 | CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2022-12-22 | — | — | US | claimed |
| US-20210387996-A1 | TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2021-12-16 | — | — | US | claimed |
| CN-112888480-A | Novel tricyclic compounds for the treatment and prevention of hepatitis b virus diseases | 豪夫迈·罗氏有限公司 | 2021-06-01 | — | — | CN | claimed |
| CN-112839714-A | Chromen-4-one derivatives for the treatment and prevention of hepatitis B virus diseases | 豪夫迈·罗氏有限公司 | 2021-05-25 | — | — | CN | claimed |
| WO-2020079106-A1 | CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-04-23 | — | — | WO | claimed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | claimed |
| US-20040142972-A1 | CNS target modulators | HYPNION, INC. | 2004-07-22 | — | — | US | claimed |
| US-11993591-B2 | Chromen-4-one derivatives for the treatment and prophylaxis of hepatitis B virus disease | HOFFMANN-LA ROCHE INC. (US) | 2024-05-28 | — | — | US | disclosed |
| US-11912721-B2 | Fused pentacyclic imidazole derivatives | UCB Biopharma SRL (BE) | 2024-02-27 | — | — | US | disclosed |
| EP-3870295-B1 | NOVEL TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2023-03-08 | — | — | EP | disclosed |
| US-20220402897-A1 | CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2022-12-22 | — | — | US | disclosed |
| CN-114072392-A | Luminescent compound or salt thereof, and polarized light-emitting element, polarized light-emitting panel, and display device each containing the same | 日本化药株式会社 | 2022-02-18 | — | — | CN | disclosed |
| CN-109195968-B | Fused pentacyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2022-02-11 | — | — | CN | disclosed |
| US-6130225-A | Substituted p-trifluoromethylphenyluracils | BAYER AKTIENGESELLSCHAFT (DE) | 2000-10-10 | — | — | US | disclosed |
| EP-0923562-A1 | SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS | BAYER AG (DE) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998006706-A1 | SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-19 | — | — | WO | disclosed |
| EP-0341910-B1 | Cephalosporins, process for their preparation, intermediates and pharmaceutical compositions | ICI PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| US-5064824-A | CEPHALOSPORIN COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-11-12 | — | — | US | disclosed |
| EP-0341910-A2 | Cephalosporins, process for their preparation, intermediates and pharmaceutical compositions | ZENECA LIMITED (GB) | 1989-11-15 | — | — | EP | disclosed |