Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5918086 | 0.90 | MAPT (0.51) | L3MBTL1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16385223 | 0.88 | SRC (0.45) | L3MBTL1KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL27799366 | 0.86 | DYRK1A (0.58) | ADORA1ALDH1A1HSD17B10CYP3A4TSHR | |
| SCHEMBL5918047 | 0.85 | MAOB (0.56) | L3MBTL1ADORA1KDM4EALDH1A1MEN1 | |
| SCHEMBL28417539 | 0.84 | SYK (0.55) | ADORA1 | |
| SCHEMBL10094711 | 0.82 | NPC1 (0.51) | L3MBTL1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL11636456 | 0.81 | KDM4E (0.64) | L3MBTL1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL20522450 | 0.80 | KDM4E (0.49) | L3MBTL1ADORA1KDM4EALDH1A1MEN1 | |
| SCHEMBL30610428 | 0.80 | KDM4E (0.49) | L3MBTL1ADORA1KDM4EALDH1A1MEN1 | |
| SCHEMBL30753776 | 0.80 | FYN (0.46) | L3MBTL1ADORA1KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320575-B | Pyridine-2-aryl-3-sulfonamide compound and synthesis method and application thereof | 浙江大学 | 2022-04-05 | — | — | CN | disclosed |
| CN-111320575-A | Pyridine-2-aryl-3-sulfonamide compound and synthesis method and application thereof | 浙江大学 | 2020-06-23 | — | — | CN | disclosed |
| US-7361662-B2 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same | LES LABORATOIRES SERVIER (FR) | 2008-04-22 | — | — | US | disclosed |
| EP-1560826-B1 | PYRIDOPYRIMIDINONE COMPOUNDS, METHOD FOR PRODUCTION THEREOF AND MEDICAMENTS COMPRISING THE SAME | SERVIER LAB (FR) | 2006-04-12 | — | — | EP | disclosed |
| US-20060041144-A1 | Phenylpyridine compound and fungicidal compostion containing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-02-23 | — | — | US | disclosed |
| US-20050288311-A1 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same | LES LABORATOIERS SERVIER (FR) | 2005-12-29 | — | — | US | disclosed |
| EP-1560826-A1 | PYRIDOPYRIMIDINONE COMPOUNDS, METHOD FOR PRODUCTION THEREOF AND MEDICAMENTS COMPRISING THE SAME | Les Laboratoires Servier (FR) | 2005-08-10 | — | — | EP | disclosed |
| EP-1541557-A1 | PHENYLPYRIDINE COMPOUND AND BACTERICIDAL COMPOSITION CONTAINING THE SAME | Sumitomo Chemical Company, Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004043956-A1 | PYRIDOPYRIMIDINONE COMPOUNDS, METHOD FOR PRODUCTION THEREOF AND MEDICAMENTS COMPRISING THE SAME | LES LABORATOIRES SERVIER (FR) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288311-A1 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same | MAP4K2, PLK2, MAP4K3 | L3MBTL1 4671/4885ADORA1 413/4885KDM4E 2184/4885 |
| US-20060041144-A1 | Phenylpyridine compound and fungicidal compostion containing the same | CBR3, CYP1A1, PAH | L3MBTL1 222/4885ADORA1 2435/4885KDM4E 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.