Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861094 | 0.81 | KDR (0.42) | BRAFEGFRABL1INSRLCK | |
| SCHEMBL14026831 | 0.80 | BRAF (0.52) | BRAFEGFRABL1CDK8CSF1R | |
| SCHEMBL4861557 | 0.78 | BRAF (0.52) | BRAFEGFRABL1NPC1RAB9A | |
| SCHEMBL14026836 | 0.77 | BRAF (0.48) | BRAFEGFRABL1CDK8CSF1R | |
| SCHEMBL4787038 | 0.77 | BRAF (0.74) | BRAFEGFRABL1LCKSRC | |
| SCHEMBL16621418 | 0.75 | HSF1 (0.67) | BRAFEGFRABL1NPC1RAB9A | |
| SCHEMBL14026832 | 0.75 | ABL1 (0.51) | BRAFEGFRABL1INSRKDR | |
| SCHEMBL4787030 | 0.73 | BRAF (0.61) | BRAFEGFRABL1LCKSRC | |
| SCHEMBL13878796 | 0.71 | LCK (0.58) | BRAFABL1INSRLCKLYN | |
| SCHEMBL4788638 | 0.71 | CSF1R (0.69) | BRAFEGFRABL1LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |