Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929461 | 0.91 | MAP2 (0.46) | FPR2PROKR1MAP2EPHX2ADRA2A | |
| SCHEMBL4023407 | 0.75 | MAP2 (0.43) | MAP2PTGS2KDM4ETSHRHSD17B10 | |
| SCHEMBL3611987 | 0.74 | MAP2 (0.47) | MAP2KDM4ETSHRHSD17B10 | |
| SCHEMBL2928734 | 0.71 | MAP2 (0.51) | MAP2ALOX15PTGS2TSHRALDH1A1 | |
| SCHEMBL2927238 | 0.71 | MAP2 (0.54) | MAP2ALOX15PTGS2HTTTSHR | |
| SCHEMBL3617971 | 0.70 | MAP2 (0.46) | MAP2KDM4ETSHRHSD17B10 | |
| SCHEMBL2924539 | 0.70 | MAP2 (0.53) | MAP2ALOX15PTGS2HTTGAA | |
| SCHEMBL2929668 | 0.70 | MAP2 (0.44) | MAP2PTGS2KDM4EALDH1A1 | |
| SCHEMBL2923342 | 0.69 | PTGS2 (0.49) | MAP2PTGS2 | |
| SCHEMBL13765393 | 0.69 | MAP2 (0.45) | MAP2LMNATP53SMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534695-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2008-06-11 | — | — | EP | disclosed |
| EP-1534695-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004014851-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-02-19 | — | — | WO | disclosed |